Rodent models in Down syndrome research: impact and future opportunities
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چکیده
منابع مشابه
Rodent models in Down syndrome research: impact and future opportunities
Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and identification of dosage-sensitive genes involved in the pathophysiology of the condition, and in expl...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2017
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.029728